1.Block USB Viruses Invest in an excellent anti-virus program that has built in USB virus scan and remover. These anti-USB virus scan programs not only protect your computer from USB Autorun viruses but can also clean worms, Trojans and viruses in your USB memory sticks.You can try anti-virus programs for USB virus such as USB Virus Scan, USB Drive Antivirus and so on. 2.Disable Your Computer’s Autorun Feature When you plug in a USB drive stick into your system, the Autorun feature initiates automatically. If your USB contains any virus programs, it’ll use the Autorun feature to infect your computer. To protect your computer, disable the Autorun feature.You can disable the Autorun feature via the Control Panel. 3.Update Your Device Driver Keeping your USB device driver updated is a good way to ensure greater stability for your USB drives. While this won’t help eradicate USB viruses, USB device drivers are constantly updated to block viruses and deliver timely warnings. You can update your USB device drive from your Windows Computer Management feature in the Control Panel. 4.Use USB Firewall Software USB firewalls prevent Windows OS from processing malicious programs when a virus infected portable USB device is opened. USB firewalls monitor only your USB devices, and not your CD and DVD drives. By using USB firewalls, you’ll be enabling a basic level of protection from the autorun.inf viruses that spread from portable USB devices. 5.Always Safely Remove USB Devices Viruses are sometimes created via damaged documents. If you are transferring a set of files to your USB drive, make sure the transfer is complete before you eject the device. Always use the Safely Remove Hardware feature of Windows OS. This is because partially transferred or damaged files can in turn corrupt other files on your USB drive. do this and enjoy..!